The incidence and complexity of mental illnesses and cognitive impairments associated with ageing and Alzheimer’s disease underscores the need to develop novel treatments. Our mission is to improve hippocampal functions in cognition.
Given the centrality of hippocampal dysfunction in neurological and psychiatric disorders and our efforts targeting convergent mechanisms (eg: PV mediated GABAergic inhibition, neuroinflammation), we aspire to develop strategies with broad therapeutic impact that improve cognition in not only Age-related cognitive decline and Mild Cognitive Impairment (MCI, Alzheimer’s disease) but also social cognition impairments in Autism spectrum disorders and overgeneralization of traumatic memories in PTSD. Take a look at our Research Page and DM me (Amar) to discuss ongoing efforts to de-risk preclinical gene therapy assets for translation.
Congrats Yu-Tzu and Jason on acceptance of your paper in Neuron.
Thank you NIH/NIMH for your continued support (R01) for our work on inhibitory circuits and social cognition
Thank you NIH/NIA for your continued support (R01) for our work on memory and aging
Congrats Hannah on the acceptance of your paper & DFG Transition Grant. Bravo and Well deserved!
Excited to share our study on Expanding the Memory reservoir in the adult brain
Thank you The Simons Collaboration on Plasticity and the Aging Brain on funding exciting new directions in the lab
Congrats Travis on NARSAD YI 2020!
Congrats Travis on our Perspective on Engrams and Memory Indexing (Neuron August 6 2020)
Watch Amar share recent work from lab on how the hippocampus communicates with subcortical circuits via lateral septum to calibrate defensive behaviors (webinar link).
Amar is named James and Audrey Foster MGH Research Scholar thanks to the generous philanthropy of James and Audrey Foster. Thank you very much for supporting our science!
Booyah! Congrats Antoine on your study identifying how a class of SST cells in the dorsolateral septum act as threat sensors and gate motion to calibrate behavioral responses to threats in the environment. Nature Neuroscience 2019. MGH EurekaAlertPress Release. HSCI Press Release
Exciting to see the NIH Director discuss and share our recent paper (Nature Medicine 2018) on how FFI maintains hippocampal indexes and remote memory precision in his monthly blog post on recent advances in science and medicine.
(March 12, 2018 Nature Medicine). Press release
Lab is awarded Ro1 from NIMH to support investigations into social memory circuits.
Congrats Cinzia on 2017 NARSAD YI Award!
Lab receives NIA R01 giving our research program traction with NIMH and NIA.
Congrats Antoine on Tosteson Fellowship!
Get in touch
Our laboratory is embedded in the Center for Regenerative Medicine at Massachusetts General Hospital and is part of a matrix that includes the Harvard Stem Cell Institute and the Department of Psychiatry at MGH.
We are members of the PhD program in the Program in Neuroscience at Harvard Medical School.
We are committed to mentoring and training the next generation of scientists to understand the workings of the brain and tackle brain disorders. The laboratory hosts individuals at all stages of their careers and I aspire to continuously evolve as a mentor.