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An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition

Shih, Alipio and Sahay,  (Neuron, Oct 4 2023) (February 2023 bioRxiv)

Covered by Spectrum Autism Research News

Write up in Harvard Brain Science Initiative -where are we going with this work? 



A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

Twarkowski et al, eLife (Accepted February 21, 2022)

Transcriptional regulation of neural stem cell expansion in the adult hippocampus

Guo et al, January 4 2022, eLife


Sustainable paths for postdoc career opportunities in industry: Lessons from failure

Craig Russo and Amar Sahay, Cell Mentor

Transcriptional regulation of neural stem cell expansion in the adult hippocampus

Guo et al, July 2021 bioRxiv


A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

Twarkowski et al, Revised November 2021, bioRxiv

Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

Choi et al, March 31 2021, Nature 



Enhancing adult neurogenesis promotes contextual fear memory discrimination and activation of hippocampal-dorsolateral septal circuits

Antoine Besnard and Amar Sahay, Behavioural Brain Research (16 September 2020)


An Integrated Index: Engrams, Place cells, and Hippocampal Memory

Travis D. Goode*, Kazumasa Z. Tanaka*, Amar Sahay#, Thomas J. McHugh#, in press, Neuron (August 6, 2020)  *co-first, # co-corresponding


Distinct dorsal and ventral CA3 outputs govern contextual fear discrimination
Besnard, Miller and Sahay, Cell Reports (Feb 18, 2020)

Independently corroborated by Opalka et al L&M 2020


Communication, Cross Talk, and Signal Integration in the Adult Hippocampal Neurogenic Niche

Vicidomini, Guo and Sahay, Neuron (Jan 22, 2020)

Heterotypic cell-cell communication regulates glandular stem cell multipotency

Centonze et al, Nature 2020.



Functions of Adult-born neurons in Hippocampal Memory Interference and Indexing

Miller and Sahay, Nature Neuroscience, Focus Issue on Learning and Memory, (September, 2019)


Dorsolateral septum somatostatin interneurons gate mobility to calibrate context-specific behavioral fear responses

Besnard et al, Nature Neuroscience (Feb 04, 2019)


Targeting Kruppel-like factor 9 in excitatory forebrain neurons protects against chronic stress-induced impairments in dendritic spines and fear responses

Besnard et al, Cell Reports (June 12)


Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Press Release. News & Views in Nature Medicine.

Guo et al, Nature Medicine (March 12, AOP)

Independently corroborated by Twarkowski et al Elife 2022 


Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

Raam et al, Nature Communications, 8 Dec 2017.  HMS Press releaseBoston Globe Metro coverage.

Independently corroborated by Meira et al Nature Communications, 2018, Lin et al JNSc 2018, Leroy et al Nature 2018

Neural Circuits serve as periscopes for NSCs

Nannan Guo and Amar Sahay, Cell Stem Cell, Perspective, 2 Nov 2017

Bone marrow drives central nervous system regeneration after radiation injury.

Dietrich J, Baryawno N, Nayyar N, Valtis YK, Yang B, Ly I, Besnard A, Severe N, Gustafsson KU, Andronesi OC, Batchelor TT, Sahay A, Scadden DT. J Clin Invest. 2017 Dec 4.


Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging

Kathleen McAvoy and Amar Sahay, Neurotherapeutics, 23 May 2017.


Neuroprotective functions for the histone deacetylase SIRT6

Shai Kaluski, Miguel Portillo, Antoine Besnard, Daniel Stein, Monica Einav, Lei Zhong, Uwe Ueberham, Thomas Arendt, Raul Mostoslavsky, Amar Sahay, Debra Toiber.

Cell Reports, 28 March 2017



Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits

Kathleen McAvoy et al.  September 1, 2016 Neuron, Advance Online Publication.

Previewed in Neuron, Research Highlights in Nature Reviews Neuroscience, NewsRoom of NIA.

Independently corroborated by Adlaf et al Elife 2017

Adult Hippocampal Neurogenesis, Fear Generalization and Stress

Besnard A, Sahay A. Neuropsychopharmacology. 2016, Stress on the Brain: Pathology, Treatment and Prevention 2016 Neuropsychopharmacology Reviews: The Next Generation of Progress Volume IX, Editors: Kerry Ressler and Jordan Smoller (Jun 12. doi: 10.1038/npp.2015.167.)



Adult hippocampal neurogenesis and pattern separation in DG: A role for feedback inhibition in modulating sparseness to govern population-based coding.

Kathleen McAvoy, Antoine Besnard and Amar Sahay. 

Frontiers in Systems Neuroscience  (2015) 9:120. PMC4542503.


Fluoxetine induces input-specific dendritic spine remodeling in adulthood and middle age 

Kathleen McAvoy, Craig Russo, Shannen Kim, Genelle Rankin, and Amar Sahay

Hippocampus, April 2015


Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors

Alexis Hill, Amar Sahay* and Rene Hen*. *Co-corresponding author.

Neuropsychopharmacology. 2015 Apr 2. doi: 10.1038/npp.2015.85


The role of adult-born neurons in mood regulation

Nannan N. Guo, Jennifer Gatchel and Amar Sahay. 

Stem Cell Biology and Regenerative Medicine.  2015 (Springer)



Adult neurogenesis modifies excitability of the dentate gyrus

Taruna Ikrar, Nannan Guo, Kaiwen He, Antoine Besnard, Sally Levinson, Alexis Hill, Hey-Kyoung Lee, Rene Hen, Xiangmin Xu and Amar Sahay.   Frontiers in Neural Circuits, 7:204, 26 Dec 2013.


Dedifferentiation of committed luminal epithelial cells into functional stem cells in vivo

Purushothama Rao Tata, Hongmei Mou, Ana Pardo-Saganta, Rui Zhao, Mythili Prabhu, Brandon M. Law, Vladimir Vinarsky, Josalyn L. Cho, Sylvie Breton, Amar Sahay, Benjamin D. Medoff and Jayaraj Rajagopal.  Nature 2013; 503(7475).

In vivo imaging of adult hippocampal neurogenesis: progress, pitfalls and promise

New Fei Ho, Jacob M Hooker, Amar Sahay, Daphne J Holt and Joshua L Roffman.    Molecular Psychiatry 2013, 18(4):404-16



Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

Mazen A. Kheirbek, Klemenhagen KC, Amar Sahay* and René Hen* (2012). Nature Neuroscience, Nov;15(12):1613-20. Epub 2012 Nov 27.   *Co-corresponding author.

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Amar Sahay*, Kimberly N. Scobie, Alexis S. Hill, Colin M. O'Carroll, Mazen A. Kheirbek, Nesha S. Burghardt, André A. Fenton, Alex Dranovsky and René Hen* (2011). Nature, April 28; 472 (7344): 466-70. * Co-corresponding author.  Covered in Leading edge, Cell 145, May 13, 2011. 

Role for neurogenesis in reducing memory interference and technical approach used here independently corroborated by Nakashiba et al Cell 2012, Adlaf et al Elife 2017, McAvoy et al Neuron 2016, Besnard et al BBR 2020, Berdugo-Vega et al Nature Communications 2020 and many other labs.

Pattern separation: A common function for new neurons in hippocampus and olfactory Bulb

Amar Sahay, Donald A. Wilson and René Hen (2011), Perspective, Special Issue: Reviews on stem cells and adult neurogenesis, Neuron, May 26, 70 (4), 582-588. 


Inducible gene expression in GFAP+ progenitor cells of the SGZ and the dorsal wall of the SVZ–

a novel tool to manipulate and trace adult neurogenesis

Tillmann Weber, Vera Baier, Rahel Pauly, Amar Sahay, Max Baur, Elke Hermann, Francesca Ciccolini, René Hen, Golo Kronenberg and Dusan Bartsch (2011). Glia April; 59(4): 615-26. 



Krüppel-like factor 9 (Klf-9) is necessary for late-phase neuronal maturation in the developing

dentate gyrus and during adult hippocampal neurogenesis

Kimberly N. Scobie, Benjamin J. Hall, Scott A. Wilke, Kristen C. Klemenhagen, Yoshiaki Fujii-Kuriyama, Anirvan Ghosh, René Hen and Amar Sahay (2009). The Journal of Neuroscience August 5; 29(31): 9875-9887.   (Cover Image)

Adult hippocampal neurogenesis in depression

Amar Sahay* and René Hen (2007), Focus on Emotion and Disorders of Emotion issue.  Nature Neuroscience 10(9):1110-1115. * Co-corresponding author.


Hippocampal neurogenesis: Depression and Antidepressant responses.

Amar Sahay, René Hen and Ronald S. Duman (2007). Adult Neurogenesis Cold Spring Harbor Monographs. 


Dentate gyrus neurogenesis and Depression

Amar Sahay, Michael R. Drew and Rene Hen (2007).   “The Dentate Gyrus: A comprehensive Guide to Structure, Function and Clinical Implications”. Editor: Helen Scharfman. Progress in Brain Research. 2007 163:697-822.



Secreted semaphorins modulate synaptic transmission in the adult hippocampus

Amar Sahay *, Chong-Hyun Kim *, Edward Cho, Jehuda Sepkuty, Richard L. Huganir, David D. Ginty and Alex L. Kolodkin (2005). The Journal of Neuroscience Apr 6; 25(14): 3613-20.  (* equal contribution)


Distinct requirements for Semaphorin 3F and Slit-1 in axonal targeting, fasciculation and

segregation of olfactory receptor sensory neuron projections 

Jean-Francois Cloutier *, Amar Sahay *, Ernie C. Chang, Marc Tessier-Lavigne, Catherine Dulac, Alex L. Kolodkin and David D. Ginty (2004). The Journal of Neuroscience Oct 13; 24(41): 9087-9096.   (* equal contribution)


Semaphorin 3F is critical for development of limbic system circuitry and is required in neurons for selective CNS axon guidance events. 

Amar Sahay, Mark E. Molliver, David D. Ginty and Alex L. Kolodkin (2003). The Journal of Neuroscience Jul 30; 23(17): 6671-80. 


Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins.

Roman J. Giger, Jean-Francois Cloutier *, Amar Sahay *, Rabinder K. Prinjha* , Dorothy V. Levengood,  Stephen E.  Moore, Susan Pickering, David Simmons, Sohaila Rastan, Frank S. Walsh, Alex L. Kolodkin, David D. Ginty, and Martin Geppert (2000). Neuron 25, 29-41.  (* equal contribution)

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